Thursday, 26 October 2017

Blind cave fish lost eyes by unexpected evolutionary process

12 October 2017

By Michael Le Page

We’ve found out why a Mexican cavefish has no eyes – and the surprising answer is likely to be seized upon by those who think the standard view of evolution needs revising.

Over the past few million years, blind forms of the Mexican tetra (Astyanax mexicanus) have evolved in caves. Maintaining eyes and the visual parts of the brain uses lots of energy, so the loss of eyes is a big advantage for animals living in the dark. Instead the cavefish “see” by sucking.

It was assumed that these fish became blind because mutations disabled key genes involved in eye development. This has been shown to be the case for some other underground species that have lost their eyes.

But Aniket Gore of the US’s National Institute of Child Health and Human Development and colleagues haven’t found any disabling changes in the DNA sequences of eye development genes in the cavefish.

Instead, the genes have been switched off by the addition of chemical tags called methyl groups. This is what is known as an epigenetic, rather than genetic, change.

“Although a central role for DNA methylation in development and disease has been well-documented, our results suggest that epigenetic processes can play an equally important role in adaptive evolution,” the team writes.


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