Dec.
12, 2012 — Box jellyfish of the Chironexspecies are among the most
venomous animals in the world, capable of killing humans with their sting.
Their venom, though, which kills by rapidly punching holes in human red blood
cells, can be slowed down by administering zinc, according to research
published December 12 in the open access journal PLOS ONE by Angel
Yanagihara from the University of Hawaii and colleagues.
The
researchers developed ways to extract venom from the jellyfish, and tested it
on human blood and on mice. They found that the venom created pores in human
red blood cells, making them leak large amounts of potassium, which causes
cardiac arrest and death.
As
Yanagihara elaborates, "For over 60 years researchers have sought to
understand the horrifying speed and potency of the venom of the Australian box
jellyfish, arguably the most venomous animal in the world. We have found that a
previously disregarded hemolysin can cause an avalanche of reactions in cells.
This includes an almost instantaneous, massive release of potassium that can
cause acute cardiovascular collapse and death."
The
authors treated the cells with a zinc compound which inhibits this process, and
found that the treatment could slow the pore-forming process in cells, and
increased survival times in the mice treated with the compound, zinc gluconate.
The research suggests that the venom's capacity to increase potassium levels is
what makes it so dangerous, and that rapid administration of zinc may be a
potential life-saver in human sting victims.
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