Showing posts with label old age. Show all posts
Showing posts with label old age. Show all posts

Wednesday, 19 April 2017

Gut bacteria affect ageing



April 19, 2017

It loses its pigments, its motor skills and mental faculties decline, it gets cancer – the turquoise killifish (Nothobranchius furzeri) struggles with the same signs of old age that affect many other living creatures. Researchers at the Max Planck Institute for Biology of Ageing in Cologne have studied the effect of intestinal microbiota on ageing and lifespan. Their results show that older animals remain active for longer and live longer if they receive the intestinal bacteria of younger members of the species. The results suggest that microorganisms in the gut affect the ageing of an organism.

The turquoise killifish is just a few months old when physical decline sets in. The African fish undergoes all the developmental stages, from hatching to dying, at speed and thus represents the ideal model organism for ageing research. Its short lifespan is comparable to that of the nematode worm C.elegans and the fruit fly Drosophila, which the researchers also studied for signs of ageing. In contrast to both of these, the killifish is a vertebrate and thus more closely related to humans than insects and worms. It means that scientists can obtain information from this fish that would otherwise take years to obtain from other vertebrates.

The turquoise killifish's gut microbiota is similar in its diversity and composition to that of humans. The microorganisms in the intestines affect the absorption of food, the metabolism and the immune system. As is the case with humans, ageing affects the composition of the microbial community: while many different species of bacteria ensure a healthy gut when young, this diversity not only diminishes in old age but the existing bacteria also contain a larger proportion of pathogens.

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Sunday, 17 November 2013

Clam-gate: The epic saga of Ming

By Rebecca Morelle, Science reporter, BBC World Service

Ming the clam reached the age of 507

The discovery that a clam called Ming reached the age of 507 has made headlines around the world.

As has the news that the scientists behind the find accidentally killed the poor old (very old) bivalve in the process of trying to work out its age.

It's an epic shellfish saga, with all the makings of a rather tasty story.

But dig a little deeper, and there's more lurking beneath the shell of this morsel of news.

"We've had emails accusing us of being clam murderers," laments Prof James Scourse from Bangor University in Wales.

Friday, 30 March 2012

Vets say dogs, cats turn old halfway through life


LOS ANGELES (AP) — Age may creep up on man, but his best friend gets there at warp speed.
Going from pup to grandpup doesn't leave much prime time under American Veterinary Medical Association labels that cats and small dogs are geriatric at 7 — and large dogs at 6.
But not everyone agrees, and rescuers say those definitions can be a death sentence to older animals in need of homes.
Dr. Emily Pointer, staff internist and medical coordinator at the American Society for the Prevention of Cruelty to Animals' Bergh Memorial Animal Hospital in New York, said she considers the last third of life the sunset years.
"That seems fairly crazy," she said of the AMVA designations. "I would never consider a person in their 40s or 50s to be senior."
The AVMA said the oldest cat on record was 34, the oldest dog was 29.
Forget the notion that seven dog years equal one human year, the AVMA said. A 7-year-old dog weighing less than 50 pounds is like a 44- to 47-year-old human; 10 equals 56- to 60-year-old humans; 15 is like a 76- to 83-year-old; and 20 is like a 96- to 105-year-old human, the group said.
Pet health improved in the 1950s and '60s when commercial dog food and vaccinations became popular and spaying and neutering increased, said Stephen Zawistowski, ASPCA executive vice president and science adviser.
Technology has advanced and today's owners are more willing to go the distance for their pets, Pointer said.
"In the past, if your cat was diagnosed with diabetes, the recommendation was probably to euthanize the cat. Now, a lot fewer people are willing to do that because it's a treatable disease," Pointer said.
Kristin Dewey of Los Angeles has an 18-year-old Ragdoll cat named Cokie. He fell from an 80-foot palm tree 16 years ago and seemed OK until four years ago when something temporarily paralyzed him and left him incontinent.
"Indoor-only cats that are loved and treated like family start to get old around 15 but can still live good lives until 19 or more. They may be a little creaky and have some health issues, but so do we all," Dewey said.
Pointer agreed: "Well-loved pets live longer than unloved pets."
"We find that most dogs become geriatric after age 12, and that at 12-ish they are like humans at 65," said Judith Piper, founder and executive director of the rescue group Old Dog Haven in Lake Stevens, Wash.
Most shelters consider dogs old at 8, Piper said, so Old Dog Haven works with dogs 8 and up.
The group tries to place the 8- to 12-year-olds they rescue from shelters and find final refuge homes for those over 12.
At age 14, Solomon is one of those final refuge or hospice dogs. Part Dalmatian and part German shepherd, he has been with Lisa Black for 30 months.
Black owns the Stardust Salon and Spa in Seattle and Solomon goes to work with her every day to greet customers. "If they don't like him, it's not the place for them," Black said.
"Old dogs are usually good with other dogs and housebroken. They are easy and don't require a lot of trips to the park. They are usually happy with us and do whatever we want," she said.
Losing them is hard, she said, but you focus on the dog. "It's what Old Dog Haven does so they don't end up alone in a shelter. We give them a happy ending," Black said.
"Even if the time they have with the dog is short, it's worth it," Piper added.
Dori Repuyan of Columbus, Ohio, says Tucker, a 60-pound German shepherd-beagle mix her family rescued nine years ago is between 11 and 13.
She worries that calling dogs old so young will cost them good homes because "people don't want old dogs."
Tucker started showing his age a few years ago, Repuyan said. He stopped running with her, limited his walking and had trouble jumping on the bed. He started going gray and when he tore a ligament, developed weight problems. Repuyan and her husband had two children and it seemed to depress Tucker, she said.
They rescued Phoebe, a small, young dog that brought Tucker out of his funk. However, Tucker now sees the vet more often, gets a supplement for arthritis and is no longer allowed on the stairs.
"It's not so much that pets are living longer than their life expectancy, although they are, but we are taking better care of them and they are surviving longer. Sixty is the new 40 is true for pets," said Fadra Nally, a writer and blogger from Raleigh, N.C.
Nally figures large dogs should be old at 8 and small dogs and cats old at 9 or 10.
Tracie Hotchner of Bennington, Vt., author of "The Dog Bible" and "The Cat Bible," believes the AVMA's numbers are right.
"It raises people's awareness of the need to get more frequent and more thorough wellness checks," she said. "Not enough people respect the fairly serious physical changes that take place in older cats and dogs and the kind of preventive care that's available."
Dogs don't have middle age, she said.
At 6 or 7, pets can experience kidney failure, digestion problems, arthritis, obesity, teeth trouble or other ailments that can be treated.
Hotchner has two older dogs with knee problems. They had surgeries, are on medication and undergoing stem cell therapy harvested from their own belly fat, she said.
The quality of their lives has been extended decisively because of those things, she said.
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