Bioelectric tweak makes flatworms grow a head instead of a tail

23 May 2017

By Jessica Hamzelou

Cut off the head of a planarian flatworm, and a new one will grow in its place. The worm is one of many creatures that have some kind of memory for lost limbs, enabling them to regenerate what was there before.

Now it seems that this memory can be altered by meddling with the electrical activity of the animals’ cells. Shifting the bioelectric current at the site of the cut changes the type of appendage regenerated – allowing a head to be regrown in place of a tail, for instance.

Michael Levin at Tufts University in Medford, Massachusetts, and his colleagues have shown that after changing the electrical current of the cells once, the animals will continue to randomly regrow a head or a tail. The findings suggest that an animal’s body plan is not just down to its genes and environment – electricity plays a key role, too. “It’s pretty profound,” says Levin.

His team has long been trying to understand how electric currents in the body’s cells affect health and the ability to regenerate damaged tissues – what Levin calls the “bioelectric code”.

On the charge

Charged ions are constantly moving in and out of cells, giving cells a natural electrical charge. The patterns of electrical activity are thought to have an important role in controlling how embryos develop limbs. Levin wants to find out whether they might work in adult animals – and potentially humans – too.

Drugs, including commonly used anaesthetics, can destabilise the electrical charge of cells. In a recent experiment, Levin’s team took this approach to see if altering the electrical charge in worms that had had their heads and their tails cut off might encourage them to grow two heads or tails instead of one head and one tail.

The team found that about 70 per cent of the worms regrew a second tail or head instead of the “correct” body part. The rest appeared to be unaffected.

To probe further, Levin’s student Fallon Durant re-cut the worms that had regenerated the normal body part without giving them any other treatment. She saw the same trend – 70 per cent regrew the wrong part, while 30 per cent looked the same as they had originally. The team repeated the experiment, and saw the same outcome over and over again.

After destabilising a worm’s electrical current once, it is as if each end of the worm makes its own decision – with a preference for the wrong part  –  as to whether it will develop a head or a tail whenever it is cut, says Levin. By altering the bioelectric code, the animal’s body plan can be permanently rewritten, he says.

Continued 

Getting a Head: How Worms Regenerate Lost Tissue

The mystery of why some animals can regenerate body parts while others cannot has long puzzled scientists, but three new studies have brought the issue to a head.

Three different research groups studied why some species of flatworms can regenerate entire heads and tails after being cut into pieces, while other species of worm only partially regenerate their body parts. By activating a single gene in the cascade of signals involved in regeneration, the researchers restored the worms' ability to grow new heads.

"In flatworms, you can cut out a single piece from any part of the worm, and somehow, magically, it turns itself into a worm," said molecular biologist Jochen Rink, who led one of the studies. The question is, "Why can some animals regenerate while others can't?" said Rink, of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany.

Continued

Why flatworms may hold the secret to immortality

British scientists believe they may have identified how humans could potentially live forever - and it’s all about flatworms

Experts at Nottingham University have been examining how two species of flatworms are able to regenerate themselves again and again – raising hopes that scientists could find ways of alleviating the effects of ageing in human cells.

Flatworms, known as planarian worms, have long fascinated scientists with their apparently limitless ability to regenerate.

During the study 20,000 new and fully-formed flatworms were created from just one original worm by splitting it into tiny pieces.

The research team studied how the flatworms manage to replace aged or damaged tissues and cells in a bid to understand what drives their longevity.

Dr Aziz Aboobaker, who led the study, said: “We’ve been studying two types of planarian worms; those that reproduce sexually, like us, and those that reproduce asexually, simply dividing in two. 

“Both appear to regenerate indefinitely by growing new muscles, skin, guts and even entire brains over and over again.



Read on:  http://uk.news.yahoo.com/why-flatworms-may-hold-the-secret-to-immortality.html