Showing posts with label cancer. Show all posts
Showing posts with label cancer. Show all posts

Sunday, 19 May 2019

How whales defy the cancer odds: Good genes


Researchers break down DNA of world's largest mammals
Date:  May 10, 2019
Source:  Arizona State University
Scientists know that age and weight are risk factors in the development of cancer. That should mean that whales, which include some of the largest and longest-lived animals on Earth, have an outsized risk of developing cancer.
But they don't. Instead, they are less likely to develop or die of this enigmatic disease. The same is true of elephants and dinosaurs' living relatives, birds. Marc Tollis, an assistant professor in the School of Informatics, Computing, and Cyber Systems at Northern Arizona University, wants to know why.
Tollis led a team of scientists from Arizona State University, the University of Groningen in the Netherlands, the Center for Coastal Studies in Massachusetts and nine other institutions worldwide to study potential cancer suppression mechanisms in cetaceans, the mammalian group that includes whales, dolphins and porpoises. Their findings, which picked apart the genome of the humpback whale, as well as the genomes of nine other cetaceans, in order to determine how their cancer defenses are so effective, were published today in Molecular Biology and Evolution.
The study is the first major contribution from the newly formed Arizona Cancer and Evolution Center or ACE, directed by Carlo Maley under an $8.5 million award from the National Cancer Institute. Maley, an evolutionary biologist, is a researcher at ASU's Biodesign Virginia G. Piper Center for Personalized Diagnostics and professor in the School of Life Sciences. He is a senior co-author of the new study.

Friday, 25 May 2018

Are humans causing cancer in wild animals?



Humans may influence cancer in many other species on the planet

Date:  May 21, 2018
Source:  Arizona State University

Summary:
As humans, we know that some of our activities can cause cancer to develop in our bodies. Smoking, poor diets, pollution, chemicals used as additives in food and personal hygiene products, and even too much sun can contribute to an increased risk of cancer. But, are human activities also causing cancer in wild animals? Researchers think so and are urgently calling for research into this topic.


Sunday, 21 February 2016

1st Case of Cancer in Naked Mole Rats Confirmed


by Laura Geggel, Staff Writer   |   February 17, 2016 02:48pm ET

Naked mole rats are renowned for their ability to live cancer-free, even when researchers try to induce the disease artificially.

Not anymore.

For the first time on record, researchers have diagnosed two naked mole rats (Heterocephalus glaber) with cancer.

"These cases represent the first formal reports of cancer in the naked mole rat, a rodent species best known for its extreme longevity and apparent resilience to typical health-span-limiting diseases, including cancer," the researchers wrote in the report, published online today (Feb. 17) in the journal Veterinary Pathology.

The finding isn't completely out of the blue. The researchers had previously followed a zoo-housed naked mole rat colony for 10 years, and found that some of the animals had precancerous lesions. But the new finding is still the first report of full-blown cancer in the critters, the researchers said.

In the first case, a 22-year-old male naked mole rat at the Brookfield Zoo in Chicago developed a mass on its upper right chest. The purple and red mass measured 0.6 inches (1.5 centimeters) in diameter. Researchers removed and studied the mass, and reported that it looked like an adenocarcinoma — a malignant tumor that likely started in the animal's mammary or salivary gland.


Wednesday, 30 December 2015

Tasmanian Devils' Mysterious Cancer May Come in Two Varieties

by Charles Q. Choi, Live Science Contributor | December 29, 2015 02:42pm ET

The Tasmanian devil has long been known to suffer from an unusual type of cancer that can spread from animal to animal, but now researchers say the endangered species is plagued by at least two kinds of infectious cancer.

The finding suggests that Tasmanian devils are especially prone to the emergence of contagious tumors, and that transmissible cancers may arise more frequently in nature than previously thought, scientists added.

Tasmanian devils (Sarcophilus harrisii) are marsupials, like kangaroos and opossums; females have pouches to carry and suckle newborns. The furry, dog-size mammals are found only on the island of Tasmania, which sits about 150 miles (240 kilometers) south of Australia. Fossil evidence suggests that Tasmanian devils were once spread across the Australian mainland, but disappeared from the area about 400 years ago. 

Saturday, 17 January 2015

Cone snail venom holds promise for medical treatments for cancer, addiction

Date:
January 14, 2015

Source:
Florida Atlantic University

Summary:
While considered a delicacy in some parts of the world, snails have found a more intriguing use to scientists and the medical profession offering a plethora of research possibilities. Cone snails are marine mollusks, just as conch, octopi and squid, but they capture their prey using venom. The venom of these marine critters provides leads for detection and possible treatment of some cancers and addictions.


Saturday, 25 January 2014

Genome of Longest-Living Cancer: 11,000-Year-Old Living Dog Cancer Reveals Its Origin, Evolution

Jan. 23, 2014 — A cancer normally lives and dies with a person, however this is not the case with a sexually transmitted cancer in dogs. In a study published in Science, researchers have described the genome and evolution of this cancer that has continued living within the dog population for the past 11,000 years.

Scientists have sequenced the genome of the world's oldest continuously surviving cancer, a transmissible genital cancer that affects dogs. This cancer, which causes grotesque genital tumors in dogs around the world, first arose in a single dog that lived about 11,000 years ago. The cancer survived after the death of this dog by the transfer of its cancer cells to other dogs during mating.

Friday, 15 March 2013

How Contagious Tasmanian Devil Cancer Goes Invisible


Stephanie Pappas, LiveScience Senior Writer
A cancer that has wiped out 70 percent of wild Tasmanian devils became contagious by "switching off" certain genes that would otherwise enable the immune system to recognize it, a new study finds.

Devil facial tumor disease is one of only two contagious cancers in the world (the other affects dogs and is nonfatal). It spreads when the Australian marsupials bite or nip each other, transmitting cancerous cells that grow into enormous face tumors. The cancer either metastasizes to other organs or prevents Tasmanian devils from eating or drinking. Either way, death usually occurs within six months. Experts predict the species could vanish within 20 years if the tumor disease isn't stopped.

The immune system should catch these tumor cells, but the cancerous invasion causes no immune response in devils, said Hannah Siddle, a University of Cambridge immunology researcher. Siddle and her colleagues have now discovered why: The tumor cells lack surface molecules called major histocompatibility complex molecules. These MHC molecules allow the immune system to detect the invading cells. Without them, the cancer is essentially invisible.


Monday, 17 December 2012

Emerging Virus in Raccoons May Provide Cancer Clues


Dec. 12, 2012 — Rare brain tumors emerging among raccoons in Northern California and Oregon may be linked to a previously unidentified virus discovered by a team of researchers, led by scientists from the University of California, Davis. Their findings, published December 12 in the journal Emerging Infectious Diseases, could lead to a better understanding of how viruses can cause cancer in animals and humans.

Necropsies conducted since March 2010 by scientists at the UC Davis School of Veterinary Medicine and UC Davis-led California Animal Health and Food Safety Laboratory found brain tumors in 10 raccoons, nine of which were from Northern California, the article reports. The 10th was sent to UC Davis by researchers at Oregon State University in Corvallis, Ore.
The common factor, found in all of the tumors, was a newly described virus, dubbed raccoon polyomavirus. Researchers suspect this virus contributes to tumor formation.

Polyomaviruses, which are prevalent but rarely cause cancer, do not typically cross from one species to another, so the outbreak is not expected to spread to people or other animals.

Two more raccoons with the tumor and the virus have been found in Yolo and Marin counties since September 2012, when the article was submitted to the journal for publication.

"Raccoons hardly ever get tumors," said study author Patricia Pesavento, a pathologist with the UC Davis School of Veterinary Medicine. "That's why we take notice when we get three tumors, much less 12."


Sunday, 11 November 2012

How Underground Rodent Wards Off Cancer: Second Mole Rat Species Has Different Mechanism for Resisting Cancer


ScienceDaily (Nov. 5, 2012) — Biologists at the University of Rochester have determined how blind mole rats fight off cancer -- and the mechanism differs from what they discovered three years ago in another long-lived and cancer-resistant mole rat species, the naked mole rat.
The team of researchers, led by Professor Vera Gorbunova and Assistant Professor Andrei Seluanov, found that abnormally growing cells in blind mole rats secrete the interferon beta protein, which causes those cells to rapidly die. Seluanov and Gorbunova hope the discovery will eventually help lead to new cancer therapies in humans. Their findings are being published this week in the Proceedings of the National Academy of Sciences.
Blind mole rats and naked mole rats -- both subterranean rodents with long life spans -- are the only mammals never known to develop cancer. Three years ago, Seluanov and Gorbunova determined the anti-cancer mechanism in the naked mole rat. Their research found that a specific gene -- p16 -- makes the cancerous cells in naked mole rats hypersensitive to overcrowding, and stops them from proliferating when too many crowd together.

Thursday, 20 September 2012

Texas University Using Dogs In Fight Against Cancer

Animal lovers will tell you-- pets have the power to heal, but what if they actually held the power to cure? Whether you're a dog owner or not, an emerging field of study at Texas A&M could someday impact you or someone you love.

Cancer touches everyone, even our pets. The human-animal bond is undeniable, but it may also prove to be invaluable in the fight to cure one of man's most deadly diseases.

"I think a dog is man's best friend in more ways than one," said Heather Wilson-Robles, a leading Veterinarian Oncology Specialist with Texas A&M's College of Veterinary Medicine and Biomedical Studies.

Experts say nothing co-exists with humans quite like dogs do. They live in our homes, play in our neighborhoods, ride our cars-- and get our cancers. That's precisely why researchers believe studying canines with cancer will help doctors understand and ultimately predict how cancer develops in humans.

"Dogs get cancer for the same reason that we do but because of their accelerated life span, they can go through that process a lot faster and so we can actually collect data, determine response rates and all those kinds of things in a much faster way," said Wilson-Robles.

Through Comparative Oncology, scientists studying dogs with cancer have dramatically helped speed up and cut down on the cost of human treatment. "Because they get cancer the same reason - we can actually use that to determine if the drugs that we want to try are actually going to work in a clinical trial," said Wilson-Robles.


Continued: http://weareaustin.com/news/top-stories/stories/texas-university-using-dogs-fight-against-cancer-4211.shtml?wap=0

Sunday, 26 August 2012

Human-Chimp Genetic Differences: New Insights Into Why Humans Are More Susceptible to Cancer and Other Diseases

ScienceDaily (Aug. 23, 2012) — Ninety-six percent of a chimpanzee's genome is the same as a human's. It's the other 4 percent, and the vast differences, that pique the interest of Georgia Tech's Soojin Yi. For instance, why do humans have a high risk of cancer, even though chimps rarely develop the disease?

In research published in September's American Journal of Human Genetics, Yi looked at brain samples of each species. She found that differences in certain DNA modifications, called methylation, may contribute to phenotypic changes. The results also hint that DNA methylation plays an important role for some disease-related phenotypes in humans, including cancer and autism.

"Our study indicates that certain human diseases may have evolutionary epigenetic origins," says Yi, a faculty member in the School of Biology. "Such findings, in the long term, may help to develop better therapeutic targets or means for some human diseases. "

Read on:
 http://www.sciencedaily.com/releases/2012/08/120823142735.htm

Saturday, 18 August 2012

New Technology Delivers Sustained Release of Drugs for Up to Six Months



ScienceDaily (Aug. 13, 2012) — A new technology which delivers sustained release of therapeutics for up to six months could be used in conditions which require routine injections, including diabetes, certain forms of cancer and potentially HIV/AIDS.

Researchers from the University of Cambridge have developed injectable, reformable and spreadable hydrogels which can be loaded with proteins or other therapeutics. The hydrogels contain up to 99.7% water by weight, with the remainder primarily made up of cellulose polymers held together with cucurbiturils -- barrel-shaped molecules which act as miniature 'handcuffs'.

"The hydrogels protect the proteins so that they remain bio-active for long periods, and allow the proteins to remain in their native state," says Dr Oren Scherman of the Department of Chemistry, who led the research. "Importantly, all the components can be incorporated at room temperature, which is key when dealing with proteins which denature when exposed to high heat."

The hydrogels developed by Scherman, Dr Xian Jun Loh and PhD student Eric Appel are capable of delivering sustained release of the proteins they contain for up to six months, compared with the current maximum of three months. The rate of release can be controlled according to the ratio of materials in the hydrogel.


Continued:
http://www.sciencedaily.com/releases/2012/08/120813203044.htm

Monday, 6 August 2012

Dog 'sniffed out cancer' in her owner's breast


A woman discovered she had a cancerous tumour in her breast after her dog started sniffing and pawing at it.
Sharon Rawlinson ignored her Cavalier King Charles Spaniel for months, but went for tests after Penny stepped on her chest, causing pain.
Mrs Rawlinson, from Newark, then examined herself and found a lump.
Penny was a surprise Christmas present which her husband almost did not buy, because he said his wife was not allowed to have another dog.
Mrs Rawlinson said 18-month-old Penny was her guardian angel.
"I can't explain how she knew. I just can't get my head around it," she said.
Penny began her unusual behaviour in November, and stepped on her owner's chest in January.
Mrs Rawlinson went to her GP and then Nottingham City Hospital for tests, and Penny continued to paw her while she waited for the results.

Saturday, 21 July 2012

Polar bear that thrived at Detroit Zoo after rescue from circus dies


A 27-year-old female polar bear that thrived at the Detroit Zoo after being rescued from a circus 10 years ago was euthanized today after she was found to be suffering from terminal cancer, zoo officials said.

Bärle (pronounced BEAR-la) was found to have extensive tumors in her abdominal cavity during a physical examination, a zoo press release said.

“We are very saddened by this loss,” said Scott Carter, Detroit Zoological Society Chief Life Sciences Officer. “Since her rescue a decade ago, Bärle has been a favorite of our staff and visitors,” Carter said in the release.

Zookeepers reported changes in Bärle’s behavior over the past five days, including a drop in appetite. Although she was given favorite foods of cooked sweet potatoes and chicken, she did not respond. During a veterinary exam this morning to assess her condition, multiple tumors were discovered and the decision was made to humanely end her life, the release said.

Monday, 16 July 2012

Ordinary Chickens May Be Extraordinary in Fighting Cancer and Other Diseases



ScienceDaily (July 10, 2012) — The common barnyard chicken could provide some very un-common clues for fighting off diseases and might even offer new ways to attack cancer, according to a team of international researchers that includes a Texas A&M University professor.

James Womack, Distinguished Professor of Veterinary Pathobiology in the College of Veterinary Medicine & Biomedical Sciences, is co-author of a paper detailing the team's work that appears in the current issue of PNAS (Proceedings of the National Academy of Sciences). Womack was a leader in the international effort to sequence the cattle genome in 2004.

Womack and the team, comprised mostly of scientists from the Seoul National University in Korea, examined 62 White Leghorn and 53 Cornish chickens for diversity in NK-lysin, an antibacterial substance that occurs naturally in animals and is used as a method of fighting off diseases.

They were able to obtain two genetic variations of NK-lysin and the results offered two unexpected shockers: both showed abilities to fight off bacterial infections and other diseases, while one showed it could successfully fight cancer cells as well.


Continued:
http://www.sciencedaily.com/releases/2012/07/120710163259.htm

Friday, 27 April 2012

Anxious Mice Face Higher Cancer Risk


Anxious mice get more serious cancer than their calmer counterparts, according to a new study that could have implications for human cancer treatments.

The research revealed that mice with anxious "personalities" — meaning animals that were more hesitant to explore potentially dangerous areas — are prone to more invasive skin cancers than coolheaded rodents. The culprit may be the damage stress does to the immune system, which can sometimes fight off these types of cancers.

"It's bad enough that cancer diagnosis and treatment generates stress and anxiety, but this study shows that anxiety and stress can accelerate cancer progression, thus perpetuating a vicious cycle," study researcher Firdaus Dhabhar, a psychiatrist at the Stanford University School of Medicine, said in a statement.

"The goal is to ameliorate or eliminate the effects of anxiety and chronic stress, at least at the time of cancer diagnosis and during treatment," Dhabhar added.

Monday, 20 September 2010

Sad demise of Cedric the Tasmanian devil sets back fight to save species

In spite of their ferocious reputation, Tasmanian devils have a timid nature. Australia Zoo / EPA
Phil Mercer, Foreign Correspondent
September 18. 2010

SYDNEY // With a spine-chilling scream that terrified Australia’s early European settlers, the carnivorous Tasmanian devil has a fearsome reputation. But in recent years it has been humans, in the form of scientists, who have been trying to save the animals from extinction.

An aggressive cancer is slowly wiping out the species, with its population falling by 60 per cent in the past decade.

Last week scientists said they had made a breakthrough in the fight to save the animals by mapping its genome for the first time. There is hope that charting the devils’ full DNA sequence will open new paths to understanding and combating the mysterious cancer that causes disfiguring facial tumours.

“This sequence is invaluable and comes at a crucial time,”said the lead researcher Elizabeth Murchison. “By comparing our draft sequence with samples taken from many hundreds of devils suffering from this cancer, we can begin to look at the spread of the disease.”

Ms Murchison, from the Australian National University, said the information would allow scientists to identify which mutations had actually caused the devils’ cancer “and perhaps allow us to target those mutant genes with particular drugs”.

The breakthrough comes after researchers suffered a setback last month when a Tasmanian devil that showed rare signs of resistance to the cancer died.

For several years the animal, named Cedric, was a beacon of hope for researchers after showing signs of immunity to the tumours.

The unique marsupials exist in the wild only in Tasmania, Australia’s rugged southern island state, where they are listed as endangered. The size of a small dog, the stocky, dark-furred marsupials have powerful jaws and a scream that led to their demonic name.

For scientists working to unlock the secrets of the virus that threatens to render devils extinct within 25 years, the untimely death of Cedric was a blow.

“He had genetic differences that we thought might lead us to find a solution to the facial tumour disease,” said Dr Barrie Wells, a veterinarian and animal welfare officer at the University of Tasmania. “It looked like Cedric might have special properties. He was a valuable animal and he did resist this disease in a way that other devils did not.”

Cedric was born in captivity and spent his whole life in research facilities, where over six years he was subjected to various tests and injected with malignant cells. He was euthanised by Dr Wells’s team at the end of August after finally succumbing to cancer.

“His death has set us back because when we thought we were close to an answer, we were not,” Dr Wells said.

The highly contagious cancer, which first emerged in the mid- 1990s and has never been seen in nature before, is transmitted between animals during rowdy communal squabbles over food or aggressive mating rituals. The search for a cure has been hampered by the contagion’s ability to mutate into several different strains.

While science struggles to find an effective treatment, breeding centres have been set up across the Australian mainland to establish “insurance” populations of healthy devils. Sydney’s Taronga Zoo is home to a small group of six adults and four juveniles, which could hold the key to the long-term survival of a species in peril.

“They have big personalities. They are very outgoing and get up to a lot of mischief,” explains Lisa Cavanagh, a keeper at the zoo, as two energetic juveniles tear into an early-morning meal of raw rabbit meat, emitting the occasional growl and squeal, while their father soaks up the sun in a nearby enclosure.

Bunyip, aged 18 months, and Devitt are unlikely to ever be released into the wild and are part of a 50-year “Noah’s ark” project to protect vulnerable captive specimens from the seemingly unstoppable sickness.

“It is an amazing disease when you see what it can do to an animal. It affects their mouth and their eyes. It is an open wound once it gets to the final stages. They live with it for about three to six months. They die not only from the cancer but from starvation. It is just the most devastating disease,” Ms Cavanagh said.

The image of the endangered Tasmanian devil has been given a makeover at a new exhibition at Taronga Zoo to raise awareness of the plight of a flesh-eating marsupial that has a fearsome reputation.

Portrayed as crazed by the Warner Brothers cartoon character Taz, the animal has never attracted the sort of public sympathy afforded to Australia’s koalas or kangaroos.

The idea is that if visitors to the zoo see how endearing and unassuming the devil usually is, they will be encouraged to support breeding programmes.

“They’ve got massive teeth and can open their mouths very wide and if there’s a bit of sun behind them their ears actually appear to glow red because of how thin the skin is, so there are a few things that do fit the name.

“However, their behaviour doesn’t quite match it,” said Nick de Vos, manager of the devil breeding programme at Taronga Zoo. “They are actually quite shy and retiring.”

Kerry Addison, a tourist from Melbourne, and her 10-year-old daughter, Rosemary, were among those happy to see one of Australia’s most distinctive mammals at such close quarters.

“They are so cute. I want one,” enthused Rosemary, while her mother said: “I think preserving as many animals as we can is important. Using the zoo to tell children about how to look after animals is a great thing. They look sweet but because they are called devils you might think they are an aggressive animal but they are obviously not and bound around quite happily.”

foreign.desk@thenational.ae

* With additional reporting by Agence France-Presse

http://www.thenational.ae/apps/pbcs.dll/article?AID=/20100919/FOREIGN/709189890/1002/rss

Friday, 21 August 2009

Tasmanian Devils’ Cancer Tackled Through Social Networks Study

By Alex Morales

Aug. 19 (Bloomberg) -- Tasmanian devils, fighting a deadly facial cancer that threatens to wipe out the species, could be saved by radio collars and an analysis of their social network.

A study of 27 of the usually solitary carnivores in Tasmania’s Narawntapu National Park showed all were connected to each other directly or through other individuals, with one male holding a central role within the network, according to a study that appeared today in the Ecology Letters journal.

The Tasmanian marsupial’s population fell by 60 percent in a decade from a fatal cancer called Devil Infectious Tumor Disease, the International Union for Conservation of Nature said. The Swiss-based group last year listed the devil as “endangered,” the second-highest degree of extinction threat.

“Understanding networks of contacts is crucial because it is usually the case that a small number of highly connected individuals, or ‘super spreaders,’ are responsible for the majority of disease transmission,” said Rodrigo Hamede, the paper’s lead author and a zoologist at the University of Tasmania. “Once these individuals are identified, actions such as targeted treatment or culling may control the disease.”

The facial cancer is spread through biting, and previous studies revealed transmission is more common during the February-March mating season, the paper said. Because mating occurs in underground burrows, past observations have been “sparse,” Hamede’s team said.

Devil Interactions

The researchers fitted 23 female devils and 23 males with radio collars that logged “contact” when they came within 30 centimeters (12 inches) of another tagged animal from February through June 2006. Usable data was recovered from 27 of the animals. The scientists’ focus was on interactions between individuals rather than incidence and transmission of the tumor.

The scientists found that during the mating season, contact between individual devils was more likely to be between males and females while outside the breeding period, female-female encounters were more common. At all times, interactions between males were “relatively uncommon.”

As few as 10,000 mature adult devils remain, confined to the Australian island-state of Tasmania, according to the IUCN. The tumor is found across 60 percent of the devil’s territory, with the group predicting a further decline in the animals’ population of 70 percent over the next decade.

While the studied population revealed one male who was a hub between many individuals, the researchers were unable to determine a specific age or sex-group that is more likely to interact with other devils.

“Our results suggest that there is limited potential to control the disease by targeting highly connected age or sex classes,” the researchers wrote. Because all the devils were connected, “The disease is capable of spreading to each individual in the population once one individual is infected.”

http://www.bloomberg.com/apps/news?pid=20601081&sid=ayh0eJZkfvuI
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