Monday, 28 November 2016

Virologists unravel mystery of late 20th century gibbon leukaemia outbreak





Date: November 17, 2016
Source: University of Nottingham

The mystery of an outbreak of lymphoma and leukemia in gibbon colonies in the US, Bermuda and Thailand in the late 1960s and early 1970s has been solved by animal disease detectives at The University of Nottingham.

The virology experts from the University's Vet School have carried out an investigation into the cancer outbreak which was caused by the gibbon ape leukemia retrovirus (GALV). They found it was most likely caused inadvertently by the unregulated international trading of gibbons and laboratory work on viruses in US military and other medical research facilities.
In a paper published in Mammal Review, the researchers crucially also found no evidence of infection in current populations of captive gibbons -- an endangered species -- and no evidence that the virus is still a threat.

Lecturer in Veterinary Cellular Microbiology, Dr Rachael Tarlinton, explained: "We thought the strange outbreak of gibbon ape leukemia and lymphoma in certain colonies fifty years ago was an enigma worth investigating, not least to see if we could find any evidence that GALV is still a problem among live populations today.

"Our review brings together published literature and laboratory records from early research into GALV which is a known contaminant of laboratory cell culture. We also analysed correspondence about the transportation of gibbons during the 60s and 70s, laboratory and zoological records to discover the origin of the retrovirus and how it could have been transmitted."

The investigation found that lymphoma and leukemia were not recorded in gibbons until the 1960s when cases were reported in gibbons in or imported to the US from south-east Asia. In 1969 cases of malignant lymphoma were reported in a single colony of white-handed gibbons in a US military research facility in Bangkok, Thailand and were at the time attributed to an unknown infectious agent. This agent was identified as GALV retrovirus, which was not native to the species, two years later when five more gibbons in the same colony were diagnosed with leukemia.

The researchers found that the virus was almost certainly inadvertently transmitted to the gibbons from rodents by medical researchers working on human diseases such as malaria and dengue fever.

The team also found that the unregulated trading of research gibbons at the time may have even caused GALV infection found in a monkey kept as a pet in a San Francisco apartment which went on to develop lymphosarcoma.

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